Transcriptional heterogeneity of HCC1143 Triple Negative Breast Cancer perturbed with paclitaxel or soluble ligand

Triple Negative Breast cancer is a heterogeneous disease that is capable of adapting to a variety of stimuli. To study the dynamics of both drug and ligand response, we performed scRNA-seq to deeply profiled the transcriptional response of the HCC1143 cell line to a variety of stimuli. HCC1143 cells were grown in vitro and treated for 24 or 72 hours with soluble perturbation.