Supplementary files to the article "Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury"

A compression spinal cord injury was performed at the T10-T11 level in mice. Injured mice received an IP treatment with baclofen (1m/kg) or the vehicle (control group) once a day for 7 days. At day 7 the spinal cord was collected (0.5 cm and -0.5 cm from the site of injury) and total RNA was extracted for transcriptomic analysis. This supplementary excel files show: 1) Differentially expressed genes between baclofen and control treated spinal cord samples. 2) Enrichment analysis. 3) Grouped enrichment analysis. 4) Transcription factor target enrichment analysis.

本研究于小鼠T10-T11节段构建压迫性脊髓损伤（compression spinal cord injury）模型。造模成功的小鼠每日接受巴氯芬（baclofen，1 mg/kg）腹腔注射（intraperitoneal, IP）或赋形剂（vehicle）对照处理，连续给药7天。造模后第7天，采集损伤位点上下0.5 cm处的脊髓组织，提取总RNA用于转录组学分析（transcriptomic analysis）。本补充Excel文件包含以下内容：1）巴氯芬处理组与对照组脊髓样本间的差异表达基因（differentially expressed genes）；2）富集分析（enrichment analysis）结果；3）分组富集分析（grouped enrichment analysis）结果；4）转录因子靶标富集分析（transcription factor target enrichment analysis）结果。