Summary of compound targets that stimulated production of IL-17A and/or IL-17Fa.

aData from the screen summarized to show compound targets that increased production of both IL-17A or IL-17F, or had selectivity for IL-17A or IL-17F in BT co-cultures. Effects of agents on IL-17A and/or IL-17F had readout values greater than log10 ratio 0.15 and were observed at 2 or more non-cytotoxic doses. The number of agents with selectivity for a specific target is shown in parentheses next to the total number of agents in the screen for that target.