Additional file 4: of Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion

Wnt-pathway-specific genes differentially expressed in ductal carcinoma in situ DCIS.COM and SUM225 mouse intraductal xenograft model (MIND) xenografts during transition from 2 to 6 weeks. Genes significantly differentially expressed between the 2- to 6-week time point in both DCIS.COM and SUM225 cell lines were further analyzed using Ingenuity Pathway AnalysisŽ (IPA). The Wnt/β-catenin canonical pathway was identified as a significantly upregulated pathway in both cell line MIND xenografts during transition from 2 to 6 weeks. (XLS 48 kb)

在2周至6周的过渡阶段中，于导管原位癌（ductal carcinoma in situ, DCIS）细胞系DCIS.COM与SUM225小鼠导管内移植瘤模型（mouse intraductal xenograft model, MIND）移植瘤内差异表达的Wnt通路特异性基因。针对DCIS.COM与SUM225两种细胞系在2周龄与6周龄时间点间存在显著差异表达的基因，采用英格诺斯通路分析（Ingenuity Pathway Analysis, IPA）开展进一步分析。在2周至6周的过渡阶段中，Wnt/β-连环蛋白经典通路被证实为两种细胞系来源的MIND移植瘤中显著上调的通路。(XLS 48 kb)