BIOGRID CURATED DATA FOR CDC28 (Saccharomyces cerevisiae (S288c))
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资源简介：
Protein-Protein, Genetic, and Chemical Interactions for CDC28 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1 (CLNs), S and G2/M (CLBs) phase cyclins, which provide substrate specificity; regulates cell cycle and basal transcription, chromosome duplication and segregation, lipid biosynthesis, membrane trafficking, polarized growth, and morphogenesis; abundance increases in DNA replication stress; transcript induction in osmostress involves antisense RNA
蛋白质-蛋白质、遗传和化学相互作用数据集，针对酿酒酵母（Saccharomyces cerevisiae (S288c)）中的CDC28基因由BioGRID（https://thebiogrid.org）编纂；定义：周期依赖性激酶（CDK）催化亚基；细胞有丝分裂和减数分裂周期的总调节者；与G1期（CLNs）、S期和G2/M期（CLBs）周期蛋白交替结合，提供底物特异性；调控细胞周期和基础转录、染色体复制和分离、脂质生物合成、膜运输、极化生长和形态发生；在DNA复制压力下含量增加；渗透压应激下的转录诱导涉及反义RNA
提供机构：
BioGRID Project
