Type 1 interferon signaling is crucial from the loss of tolerance nd the development of autoreactive B cells.

The transcriptomes of FACS-sorted B220+GL7+CD95+ germinal center B cells and B220+GL7-CD95- non-germinal center B cells from lupus-prone B6.Sle1b were compared to the same cell types in B6.Sle1b mice without the type 1 interferon receptor (B6.Sle1b.IFNaR1-/-). Overall design: Examination of effect of IFNaR1 signaling on B cell selection in autoimmune-prone germinal centers.