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Mapping transcriptionally engaged RNA polymerase II in C2C12 myoblasts

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https://www.ncbi.nlm.nih.gov/sra/SRP068191
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资源简介:
A large portion of the mammalian genome is associated with the nuclear lamina (NL). Here we have documented genome-wide transcriptional activities by measuring the densities, locations and orientations of transcriptionally-engaged RNA polymerase II in mouse C2C12 myoblasts using global run-on sequencing. Interestingly, a significant fraction (~20%) of NL-associated genes were detected to be transcriptionally active. Overall design: Mapping transcriptionally engaged RNA polymerase II by global run-on sequencing (GRO-seq)
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2020-07-21
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