Dataset: Comparison of Quantra® QPlus® System to Thromboelastography in Cardiac Surgery

Use of viscoelastic testing such as thromboelastography (TEG) is recommended in cardiac surgery to monitor coagulation and to guide the transfusion of blood products. The Quantra® QPlus® System is a novel point-of-care platform using sonic estimation of elasticity via resonance sonorheometry that can assess viscoelastic properties of a clot as it forms. Twenty-eight patients undergoing elective cardiac surgery using CPB were evaluated in this prospective observational study. Perioperative citrated blood samples were collected in the operating room and assessed using Quantra and results were compared with TEG and conventional coagulation testing (CCT). Method comparison using Deming Regression analysis demonstrated that Quantra parameters (Quantra clot time (CT), clot stiffness (CS) and fibrinogen contribution to clot stiffness (FCS)) significantly correlated with the TEG R and TEG G after induction of anesthesia, on-CPB, and following re-warming (rs=0.83, rs=0.84, and rs=0.73, respectively). However, Quantra parameters demonstrated poor agreement and significant proportional bias when compared to equivalent TEG5000 parameters. This data demonstrates that the Quantra QPlus System is suitable for investigating coagulopathy associated with cardiac surgery requiring CPB. Despite the strength of correlation between Quantra and TEG parameters, equivalent measurements are not interchangeable.

心脏外科手术中推荐采用血栓弹性描记法（thromboelastography, TEG）这类黏弹性检测技术，用于监测凝血状态并指导血液制品输注。Quantra® QPlus®系统是一款新型床旁检测（point-of-care）平台，采用基于共振声波流变学的弹性声波评估技术，可在血凝块形成过程中评估其黏弹性特性。本前瞻性观察研究纳入28例行择期体外循环（cardiopulmonary bypass, CPB）心脏手术的患者进行评估。研究于手术室采集围手术期枸橼酸化血液样本，采用Quantra系统进行检测，并将结果与TEG及常规凝血检测（conventional coagulation testing, CCT）进行对比。采用戴明回归分析（Deming Regression）进行方法学对比的结果显示，在麻醉诱导后、体外循环期间及复温后，Quantra检测参数[包括Quantra凝血时间（clot time, CT）、血凝块硬度（clot stiffness, CS）及纤维蛋白原对血凝块硬度的贡献值（fibrinogen contribution to clot stiffness, FCS）]分别与TEG的R值及G值呈显著相关（相关系数rs分别为0.83、0.84及0.73）。但相较于对应型号的TEG5000检测参数，Quantra检测参数的一致性较差，且存在显著的比例偏倚。本研究数据表明，Quantra QPlus®系统适用于评估需行体外循环的心脏手术患者相关的凝血病。尽管Quantra与TEG的检测参数间存在较强相关性，但二者的等效检测结果并不能互换使用。