Regiospecific Organocatalytic Asymmetric Aldol Reaction of Methyl Ketones and α,β-Unsaturated Trifluoromethyl Ketones

The aldol reaction of methyl ketones and α,β-unsaturated trifluoromethyl ketones occurred under mild conditions with the combination of
proline-derived N-sulfonylamide and trifluoroacetic acid as the catalyst to give the corresponding unsaturated α-trifluoromethyl tertiary alcohols
in high yields with good enatioselectivities.