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METTL3-m6A methylation inhibits Type II Alveolar Epithelial Cells proliferation and viability by promoting Pten mRNA stability and translation efficiency in the acute lung injury. METTL3-m6A methylation inhibits Type II Alveolar Epithelial Cells proliferation and viability by promoting Pten mRNA stability and translation efficiency in the acute lung injury

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NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1078760
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In this dataset, we include the m6A methylated RNA data obtained from normal AECII (NC group) and AECII transfected with shMettl3 (T group). Overall design: We generated the following comparisons using Fold-change (FC) ≥ 2 or ≤ 0.5, and p < 0.05 were used to identify the differentially m6A methylated RNAs.The total RNAs were immunoprecipitated with anti-N6-methyadenosine (m6A) antibody. The modified RNAs were eluted from the immunoprecipitated magnetic beads as the “IP”. The unmodified RNAs were recovered from the supernatant as “Sup”. Two channel arrays were used for these samples but the data were analyzed as single-channel so that each sample represents either IP or supernatent and the sample table includes the normalized signal values. Pleaes note that each raw data file contains both IP and SUP raw data and is linked to the corresponding IP sample records.
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2024-02-21
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