Identification of circRNA and mRNA expression profiles and functional networks of vascular tissue in lipopolysaccharide-induced rat septic shock model [circRNA]

Septic shock is the most common cause of death in intensive care units. The aim of this study is to investigate the role of circular RNA (circRNA) and mRNA expression profiles and functional networks in aortic tissue of septic shock. Septic shock model in rats was established by intraperitoneal injection of lipopolysaccharide (LPS). High-throughput sequencing and bioinformatics analysis were performed on aortic tissue to identify differentially expressed (DE)circRNAs, which were validated by qRT-PCR. We performed bioinformatics analysis and constructed circRNA-mRNA and circRNA-miRNA-mRNA networks to investigate mechanisms related to biological functions and signaling pathways. Then, functional and pathway enrichment analyses were performed.