“On Water” Direct Organocatalytic Cyanoarylmethylation of Isatins for the Diastereoselective Synthesis of 3‑Hydroxy-3-cyanomethyl Oxindoles
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下载链接：
https://figshare.com/articles/dataset/_On_Water_Direct_Organocatalytic_Cyanoarylmethylation_of_Isatins_for_the_Diastereoselective_Synthesis_of_3_Hydroxy-3-cyanomethyl_Oxindoles/7868579
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资源简介：
An “on water”
organocatalytic cyanoarylmethylation
of aryl acetonitrile to isatins is developed, giving products in high
yields and up to excellent diastereoselectivities. A remarkable enhancement
of reaction rates and diastereoselectivities by water was observed
under mild conditions. Moreover, this approach provides a highly efficient
and environmentally benign access to thermodynamic 3-hydroxy-3-cyanomethyl
oxindoles.
创建时间：
2019-03-20
