Identifying ASCL1-mediated chromatin changes in primary GBM stem cell cultures [ATAC-seq]
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
ASCL1 mediates neuronal differentiation of GBM stem cell (GSC) cultures. We sought to identify chromatin changes upon induced ASCL1 expression in primary human GSC cultures. In this dataset, we include ATAC-seq data obtained from GSC cultures harbouring a CRISPR-deletion of ASCL1. We assessed differential ASCL1 binding between control and GSC cultures induced to overexpress ASCL1 after 14 days of doxycycline treatment.
转录因子ASCL1介导胶质母细胞瘤干细胞 (GBM stem cell, GSC) 培养物的神经元分化。本研究旨在鉴定原代人GSC培养物中诱导ASCL1表达后发生的染色质改变。本数据集包含携带ASCL1基因CRISPR敲除的GSC培养物的ATAC测序 (ATAC-seq) 数据。我们评估了经多西环素处理14天后、被诱导过表达ASCL1的GSC培养物与对照组之间的差异ASCL1结合情况。
提供机构：
The Hospital for Sick Children
创建时间：
2022-02-20
