Compensatory growth is accompanied by changes in insulin-like growth factor-1 but not markers of cellular aging in a long-lived seabird

Developing organisms often plastically modify growth in response to environmental circumstances, which may be adaptive, but is expected to entail long-term costs. However, the mechanisms that mediate these growth adjustments and any associated costs are less well understood. In vertebrates, one mechanism that may be important in this context is the highly conserved signaling factor insulin-like growth factor-1 (IGF-1), which is often positively related to post-natal growth and negatively related to longevity. To test this idea, we exposed captive Franklin’s gulls (Leucophaeus pipixcan) to a physiologically relevant nutritional stressor by restricting food availability during post-natal development and examined the effects on growth, IGF-1, and two potential biomarkers of cellular and organismal aging (oxidative stress, and telomeres). During food restriction, experimental chicks gained body mass more slowly and had lower IGF-1 levels than controls. Following the food restriction, experi..., This dataset contains multiple CSV files and the accompanying R script. The \"primarydataset.csv\" file includes feeding period, sampling period, absolute growth rates (g/day), IGF-1 concentrations (ng/mL), T/S ratios (note: this is a comparative metric- these values can only be compared to other T/S ratios that were run on the same plates), regression to the mean values (note: this value was calculated using a separate formula described in Verhulst 2013), principle component values (values calculated from wing chord (mm), head to bill length (mm), and culmen length (mm)), and daily body mass (in grams). This file also contains two measures associated with measuring oxidative stress including antioxidant capacity and protein carbonyl content.  Median absolute growth rates were calculated from the daily body mass values. Several supplementary datasets have also been included in this folder, including the \"hatch.csv\" dataset which contains chick hatch date, whether or not chicks hatched, ti..., R is needed to open the R script, all excel files have been uploaded as .csv.

发育中的生物常可根据环境条件进行生长的可塑性调控，此类调控或具备适应性，但通常会伴随长期代价。然而，介导此类生长调整及其相关代价的具体机制，目前仍未得到充分阐明。
在脊椎动物中，与此过程相关的一类重要机制为高度保守的信号因子胰岛素样生长因子-1（IGF-1, insulin-like growth factor-1），其通常与出生后生长呈正相关，而与寿命呈负相关。
为验证这一假说，我们通过限制圈养条件下的富兰克林鸥（Leucophaeus pipixcan）幼鸟在出生后发育阶段的食物供给，施加了符合生理相关水平的营养胁迫，并以此考察其对生长、IGF-1水平，以及两种潜在的细胞与个体衰老生物标志物（氧化应激与端粒）的影响。在食物限制阶段，实验组幼鸟的体重增长速率显著慢于对照组，且IGF-1水平更低。在食物限制阶段结束后，实验组……。
本数据集包含多个CSV格式文件及配套的R脚本。其中"primarydataset.csv"包含以下字段：投喂周期、采样周期、绝对生长速率（单位：克/天）、IGF-1浓度（单位：纳克/毫升）、T/S比值（注：该指标为相对比较参数，仅可与同一检测板上测定的其他T/S比值进行比对）、均值回归值（注：该值通过Verhulst 2013年描述的独立公式计算得到）、主成分分析值（由翼弦长度（毫米）、头喙长（毫米）以及嘴峰长（毫米）计算得出），以及每日体重（单位：克）。该文件同时包含两项与氧化应激检测相关的指标：抗氧化能力与羰基蛋白含量。绝对生长速率的中位数由每日体重数据计算得到。
本文件夹同时包含若干补充数据集，例如"hatch.csv"，其包含幼鸟出雏日期、是否成功出雏等信息，……。运行该配套R脚本需依赖R语言环境，所有Excel文件均已转换为CSV格式上传。