EGFR/MAPK signaling pathway as a target for sulforaphane-rescued heart tube malformation induced by various concentrations of PhIP exposure

we offered an insight for the first time that PhIP exposure indeed increased the risk of abnormality of early cardiogenesis, and SFN was able to rescue various concentrations of PhIP-induced abnormal heart tube formation through targeting EGFR and mediating EGFR/MAPK signaling pathway, a previously unobserved regulatory process.