Supplementary Material for: The Rate of Magnetic Resonance Imaging in Patients with Deep Brain Stimulation

<b><i>Background:</i></b> For Parkinson's disease (PD), essential tremor (ET), and dystonia patients with deep brain stimulation (DBS) implants, magnetic resonance imaging (MRI) requires additional safety considerations due to potentially hazardous interactions. <b><i>Objective:</i></b> A propensity-matched cohort of DBS-implanted patients was analyzed to determine the likelihood of needing MRI. <b><i>Methods:</i></b> Patients with new DBS full-system implants (n = 576) were identified in the Truven Health MarketScan® Commercial Claims and Medicare Supplemental Databases (2009-2012). Patients diagnosed with PD, ET, or dystonia and no DBS implant were identified (DBS-indicated patients: n = 11,216). The DBS-indicated patients were continuously enrolled for 4 years and matched for age, gender, and propensity score based on comorbid conditions to DBS-implanted patients (n = 4,878 and 543, respectively). A Kaplan-Meier survival curve of time to first MRI was extrapolated to 10 years. <b><i>Results:</i></b> An estimated 56-57% of DBS-indicated patients need an MRI within 5 years and 66-75% within 10 years after implantation. While 92% of DBS-implanted patients' MRI after implantation was of the head, for DBS-indicated patients, 62% of MRIs were of the body, potentially unrelated to the primary diagnosis. <b><i>Conclusions:</i></b> This analysis highlights the projected utilization of MRI in the DBS population for head and full-body images.

<b><i>背景：</i></b> 对于植入脑深部电刺激（deep brain stimulation, DBS）装置的帕金森病（Parkinson's disease, PD）、原发性震颤（essential tremor, ET）及肌张力障碍患者而言，磁共振成像（magnetic resonance imaging, MRI）检查需额外考量安全性，因二者间可能存在危险的相互作用。<b><i>研究目的：</i></b> 本研究针对匹配倾向性得分的植入DBS患者队列展开分析，以明确患者接受MRI检查的概率。<b><i>研究方法：</i></b> 2009-2012年，从Truven Health MarketScan®商业理赔与医疗保险补充数据库中，筛选出全新全系统植入DBS的患者（n=576）；同时筛选出确诊为PD、ET或肌张力障碍且未植入DBS的患者（即DBS适应证患者，n=11216）。将随访满4年的DBS适应证患者，依据共病情况匹配年龄、性别及倾向性得分，与植入DBS的患者进行配对（两组样本量分别为4878例与543例）。将首次MRI检查时间的Kaplan-Meier生存曲线外推至10年随访周期。<b><i>研究结果：</i></b> 据估计，56%~57%的DBS适应证患者会在植入后5年内接受MRI检查，66%~75%的患者会在植入后10年内接受该项检查。植入DBS的患者中，92%的术后MRI检查为头部MRI；而DBS适应证患者中，62%的MRI检查为全身MRI，此类检查或与原发诊断无直接关联。<b><i>研究结论：</i></b> 本分析明确了DBS植入人群中头部及全身MRI检查的预估使用率。