Chlamydomonas reinhardtii Genome sequencing for SNP library construction

Whole genome sequencing is a powerful tool to detect changes in genomic DNA. However, how to identify a causative mutation from over 20,000 changes remains a big challenge. For the unicellular green alga Chlamydomonas, we built a library that consists of over 2 million changes from 16 strains. This SNP library is useful to eliminate non-relevant changes from mutants of interest in order to facilitate the identification of causative mutations.