Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration: part II

We identified that microRNA-150 is upregulated in aged macrophages of diverse origins and therefore may mechanistically skew them towards a disease-promoting phenotype. The purpose of this experiment was to identify how the murine transcriptome changes with microRNA-150 overexpression.我们发现，微RNA-150（microRNA-150）在多种来源的衰老巨噬细胞中呈现上调表达状态，因此可从机制层面促使这类巨噬细胞向促疾病表型偏移。本实验旨在探究小鼠转录组在微RNA-150过表达条件下的变化情况。