NoDaMS

Nocardiosis is on the rise but hard to diagnose and the application of advanced subtyping technologies iscalled for. While the genomic sequence for the most virulent strain, Nocardia farcinica is available, proteome data are essentially non-existent. The two-dimensional gel images of all strains are similar and dominated by housekeeping proteins such as chaperones and metabolic enzymes. The sequences
of many proteins are highly homologous among strains and in some cases Mycobacterium sequences are closer matches to the unknown than those of N. farcinica.

诺卡菌病（Nocardiosis）的发病率呈逐年上升趋势，但临床诊断难度较大，亟需应用先进的亚型分型技术。目前，致病性最强的菌株——鼻疽诺卡菌（Nocardia farcinica）的基因组序列已公开，但对应的蛋白质组（proteome）数据几乎完全缺失。所有菌株的二维凝胶电泳图像均较为相似，且主要由管家蛋白（housekeeping proteins）构成，例如分子伴侣（chaperones）与代谢酶类。多数蛋白质的序列在不同菌株间具有高度同源性；在部分场景中，分枝杆菌属（Mycobacterium）的序列与未知诺卡菌蛋白序列的匹配度，甚至高于鼻疽诺卡菌的对应序列。