F-statistics for imaging-derived phenotypes (IDPs).

Briefly, the F-statistic is derived as R2×(N-M-1) / (1-R2)×M, where R2 denotes the explained variance of instrumental SNPs, N denotes the sample size, and M denotes the total number of instrumental SNPs. The instrumental SNPs for F-statistic computation are the ones kept after the winner’s curse correction in MR-PL. Besides, the two IDPs (Field ID 25062 and 25063) that were discarded after the winner’s curse correction due to a lack of associated instrumental SNPs are labeled as red, which happened to have F-statistics less than 10. FieldID: the corresponding field ID information for these IDPs in the UK Biobank. (XLSX)