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Induction of Immortal-like CAR-T Cells by Defined Factors (bulk RNA-seq)

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NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE190189
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In order to investigate the underlying mechanism, we determined to profile the transcriptional status of CAR19TIF cells and sgZcsh12a CAR T cells derived from spleens of recipient mice at Day-10 post cell transfer and CAR19TIF cells and endogenous CD8 T cells derived from spleens of recipient mice at 3-month post cell transfer. Thy1.1+ CAR19TIF and sgZc3h12a CAR19T cells derived from recipient mice were isolated and purified on Day-10 post cell transfer. And Thy1.1+ CAR19TIF and endogenous CD8 T cells derived from recipient mice were processed by same procedure on 3-month post cell transfer.
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2024-03-07
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