five

circRNA sequencing in breast cancer patient tissues

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1214847
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we identified a circular RNA circARHGAP12, which was high-expressed in trastuzumab resistant HER2+ BC tumors and cell lines. We proved that circARHGAP12 promoted trastuzumab resistance by interacting with the FAK protein and may serve as a novel biomarker and potential therapeutic target for reversing trastuzumab resistance in HER2-positive breast cancer.
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2025-01-23
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