Enantioselective Allylic Alkylation with 4‑Alkyl-1,4-dihydro-pyridines Enabled by Photoredox/Palladium Cocatalysis

Highly regio- and
enantioselective allylic alkylation has been
achieved enabled by the merger of photoredox and palladium catalysis.
In this dual catalytic process, alkyl radicals generated from 4-alkyl-1,4-dihydropyridines
act as the coupling partners of the π-allyl palladium complexes.
The generality of this method has been illustrated through the reaction
of a variety of allyl esters with 4-alkyl-1,4-dihydropyridines. This
mechanistically novel strategy expands the scope of the traditional
Pd-catalyzed asymmetric allylic alkylation reaction and serves as
its alternative and potential complement.