Effects of sub-acute exposure of NOAEL-dose neonicotinoid clothianidin on the gene expression profiles of cerebral cortex and hippocampus in male mice

Neonicotinoid pesticides cause behavioral abnormalities in mammals, raising concerns about their effects on neural function. We investigated effects of sub-acute exposure to a neonicotinoid pesticide, clothianidin (CLO) on gene expression profiles of the cerebral cortex and hippocampus in male mice Male mice were administrated no observed adverse effect level (NOAEL; 50 mg/kg/day) of CLO or vehicle (1% DMSO) for 2 weeks.