Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine.
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Experimental data from <br> Modeling Na<sub>V</sub>1.1/<em>SCN1A </em>sodium channel mutations in a microcircuit with realistic ion concentration<br> dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic<br> migraine. <br> Louisiane Lemaire<sup>1,2,*</sup>, Mathieu Desroches<sup>1,2</sup>, Martin Krupa<sup>1,3</sup>, Lara Pizzamiglio<sub>5,6</sub>, Paolo<br> Scalmani<sup>4</sup>, Massimo Mantegazza<sup>5,6,7,**</sup> <br> 1 Inria Sophia Antipolis Méditerranée Research Centre, MathNeuro Team, Valbonne-Sophia Antipolis,<br> France.<br> 2 Université Côte d’Azur, Nice, France.<br> 3 Université Côte d’Azur, Laboratoire Jean-Alexandre Dieudonné, Nice, France.<br> 4 U.O. VII Clinical and Experimental Epileptology, Foundation IRCCS Neurological Institute Carlo<br> Besta, Milan, Italy.<br> 5 Université Côte d’Azur, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia<br> Antipolis, France.<br> 6 CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis,<br> France.<br> 7 Inserm, Valbonne-Sophia Antipolis, France. Corresponding authors:<br> * louisiane.lemaire@inria.fr<br> ** mantegazza@ipmc.cnrs.fr https://hal.archives-ouvertes.fr/hal-03191275
