Table1_BDNF-loaded chitosan-based mimetic mussel polymer conduits for repair of peripheral nerve injury.DOCX

Care for patients with peripheral nerve injury is multifaceted, as traditional methods are not devoid of limitations. Although the utilization of neural conduits shows promise as a therapeutic modality for peripheral nerve injury, its efficacy as a standalone intervention is limited. Hence, there is a pressing need to investigate a composite multifunctional neural conduit as an alternative treatment for peripheral nerve injury. In this study, a BDNF-loaded chitosan-based mimetic mussel polymer conduit was prepared. Its unique adhesion characteristics allow it to be suture-free, improve the microenvironment of the injury site, and have good antibacterial properties. Researchers utilized a rat sciatic nerve injury model to evaluate the progression of nerve regeneration at the 12-week postoperative stage. The findings of this study indicate that the chitosan-based mimetic mussel polymer conduit loaded with BDNF had a substantial positive effect on myelination and axon outgrowth. The observed impact demonstrated a favorable outcome in terms of sciatic nerve regeneration and subsequent functional restoration in rats with a 15-mm gap. Hence, this approach is promising for nerve tissue regeneration during peripheral nerve injury.

对周围神经损伤患者的护理工作复杂多样，传统方法亦存在其局限性。尽管神经导管在治疗周围神经损伤方面展现出一定前景，但其作为单一干预手段的疗效有限。因此，迫切需要研究一种复合多功能神经导管作为周围神经损伤的替代治疗方案。在本研究中，制备了一种负载有脑源性神经营养因子（BDNF）的壳聚糖仿生贻贝聚合物导管。其独特的粘附特性使其无需缝合，改善损伤部位的微环境，并具有良好的抗菌性能。研究人员利用大鼠坐骨神经损伤模型，在术后12周评估神经再生的进展。研究结果表明，负载有BDNF的壳聚糖仿生贻贝聚合物导管对髓鞘形成和轴突生长具有显著的促进作用。观察到的效应在坐骨神经再生及随后大鼠15毫米间隙处功能恢复方面展现出良好的结果。因此，该策略在周围神经损伤期间的神经组织再生中具有广阔的应用前景。