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Pd-Catalyzed Tandem sp2–sp3 Coupling Reactions of Chiral Stannolanes: An Efficient Preparation of Optically Active Tetrahydrobenz[f]isoindoles

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Figshare2016-02-19 更新2026-04-29 收录
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A novel double Migita–Kosugi–Stille coupling reaction with dihydrostannolanes, which are readily available from a radical cascade reaction, was achieved with dihalobenzenes in the presence of a palladium catalyst. Use of unsymmetrical 1-bromo-2-iodobenzene derivatives accomplished the double coupling reaction which gave tetrahydrobenz[f]isoindoles in a regioselective manner.

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2016-02-19
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