An integrative review of associations between polymorphic variants and the metabolic syndrome

Abstract The pathogenesis of metabolic syndrome, i.e. of each of its components, is complex and has not been entirely elucidated. As a result, it is very difficult to establish a definition of which clinical factors are the most important determinants of its development. The objective of this review is to describe Brazilian scientific research investigating associations between the metabolic syndrome and genetic factors. We selected fifteen studies that met the inclusion and exclusion criteria. Our analysis revealed that there is a modest volume of Brazilian studies investigating relationships between genes, their polymorphic variants and the metabolic syndrome and its risk factors. Therefore, more studies are needed to better understand the biological roles played by genetic polymorphisms and their relationships with metabolic syndrome or its risk factors.

摘要 代谢综合征（metabolic syndrome）及其各组分的发病机制十分复杂，目前尚未完全阐明。正因如此，明确哪些临床因素是其发生发展最重要的决定因素极具难度。本综述旨在梳理巴西学界针对代谢综合征与遗传因素之间关联开展的科学研究。我们共筛选出15项符合纳入与排除标准的研究。分析结果显示，巴西现有相关研究中，围绕基因及其多态性变异与代谢综合征及其危险因素之间关联的研究体量相对有限。因此，仍需开展更多研究，以更深入地阐明遗传多态性所发挥的生物学作用，及其与代谢综合征或其危险因素之间的关联。