PLA2G3

This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]

本基因编码一种属于分泌型磷脂酶A2家族的蛋白质，该家族成员包括蜜蜂毒液酶。编码的酶在脂质代谢中发挥作用，并催化磷脂sn-2酰基键的钙依赖性水解，从而释放花生四烯酸和溶血磷脂。此酶作为纤毛发生负调节因子，可能通过刺激肿瘤细胞生长和血管生成在癌症发展中发挥一定作用。该基因与氧化应激相关，且该基因的多态性与其与阿尔茨海默病风险相关联。[由RefSeq提供，2014年4月]