KRT10
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1354394
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资源简介：
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
本基因编码属于I型（酸性）细胞角蛋白家族的成员，该家族隶属于中间丝（IF）蛋白的超家族。角蛋白是异源多聚的结构蛋白，构成中间丝。这些中间丝与肌动蛋白微丝和微管一起，共同构成了上皮细胞的细胞骨架。本基因的突变与表皮溶解性过度角化病相关。该基因定位于17q21染色体上角蛋白家族成员的簇中。[由RefSeq提供，2008年7月]
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