The effect of secretor status and the vaginal microbiome on birth outcome

To test the hypothesis of that maternal secretor status (by mutated FUT2 gene) might influence the composition of the vaginal microbiota in pregnancy, the study analysed the relationship between secretor status, vaginal microbiota and gestational length in an ethnically diverse cohort of 313 pregnant women, including 91 who delivered prematurely. The results point towards stratification by secretor status as an important factor for considering preterm birth risk and prevention.

为验证"母体分泌型状态（由突变的FUT2基因决定）可能影响妊娠期间阴道微生物群组成"这一假说，本研究针对313名不同种族的妊娠女性队列（其中91例为早产分娩者），分析了分泌型状态、阴道微生物群与妊娠时长之间的关联。研究结果表明，按分泌型状态进行分层，是评估早产风险与制定预防策略时需考量的重要因素。