The Human Protein Atlas

The Human Protein Atlas portal is a publicly available database with millions of
high-resolution images showing the spatial distribution of proteins in 46 different normal human tissues
and 20 different cancer types, as well as 47 different human cell lines. The data is released together
with application-specific validation performed for each antibody, including immunohistochemisty, Western
blot analysis and, for a large fraction, a protein array assay and immunofluorescent based confocal
microscopy. The database has been developed in a gene-centric manner with the inclusion of all human
genes predicted from genome efforts. Search functionalities allow for complex queries regarding protein
expression profiles, protein classes and chromosome location.

人类蛋白质图谱（Human Protein Atlas）门户是一款公开可获取的数据库，拥有数百万张高分辨率图像，展示了46种正常人体组织、20种不同癌症类型以及47种不同人类细胞系内蛋白质的空间分布特征。该数据集发布时同步附带针对每种抗体完成的应用特异性验证工作，包括免疫组织化学（immunohistochemistry）、蛋白质免疫印迹（Western blot）分析；针对大部分样本，还开展了蛋白质阵列检测以及基于免疫荧光的共聚焦显微镜成像实验。该数据库以基因为中心进行构建，纳入了所有通过基因组研究预测得到的人类基因。其内置的搜索功能支持针对蛋白质表达谱、蛋白质类别以及染色体定位的复杂查询。

搜集汇总

背景与挑战

背景概述

The Human Protein Atlas是一个公开的蛋白质数据库，提供数百万张高分辨率图像，展示蛋白质在多种正常组织和癌症中的分布，并包含详细的抗体验证数据。数据库以基因为中心，支持复杂查询功能。