Additional file 1: of Impact of early events and lifestyle on the gut microbiota and metabolic phenotypes in young school-age children

Table S1. Summary of phenotypic information of Dutch children at 6â 9â years of age. Table S2. Sequencing statistics for fecal samples of Dutch children. Table S3. Summary of phenotypic and sequencing information of Dutch adults. Table S4. List of genera that differ significantly in abundance between Dutch children and adults. Table S5. List of species that differ significantly in abundance between Dutch children and adults. Table S6. Dirichlet multinomial mixtures (DMM)-based enterotypes in Dutch children. Table S7. List of genera that differ significantly in abundance between enterotypes. Table S8. List of species that differ significantly in abundance between enterotypes. Table S9. Number of genes annotated at the genus level in enterotypes. Table S10. Differential enrichment of KEGG modules between enterotypes. Table S11. Differences in host phenotypic parameters between enterotypes. Table S12. Generalized linear analysis for the association between pre-school dietary factors and school-age blood metabolic parameters. Table S13. Taxa distributions of genes involved in butyrate and succinate production. Table S14. List of genes involved in butyrate, propionate and succinate production. (XLSX 241 kb)

表S1. 荷兰6~9岁儿童表型信息汇总。表S2. 荷兰儿童粪便样本测序统计。表S3. 荷兰成年人表型与测序信息汇总。表S4. 荷兰儿童与成年人肠道菌群丰度存在显著差异的菌属列表。表S5. 荷兰儿童与成年人肠道菌群丰度存在显著差异的菌种列表。表S6. 基于狄利克雷多项混合模型（Dirichlet multinomial mixtures, DMM）的荷兰儿童肠型。表S7. 不同肠型间丰度存在显著差异的菌属列表。表S8. 不同肠型间丰度存在显著差异的菌种列表。表S9. 各肠型中属水平注释的基因数量。表S10. 不同肠型间KEGG模块的差异富集情况。表S11. 不同肠型间宿主表型参数的差异。表S12. 学龄前膳食因素与学龄期血液代谢参数关联的广义线性分析结果。表S13. 参与丁酸与琥珀酸生成的基因的类群分布。表S14. 参与丁酸、丙酸与琥珀酸生成的基因列表（XLSX 241 kb）