Exosomes from cisplatin-induced dormant A549 cells activated the glycolysis of BMSCs

Lung cancer is the leading cause of cancer-related deaths worldwide. Chemotherapy kills most cancer cells, however, the residual cells enter into dormant state. The dormant cancer cells can be reactivated under specific circumstances. The "premetastatic niche" that is suitable for colonization of cancer cells is formed before the arrival of cancer cells. Tumor-derived exosomes are the main mediators of tumorigenesis. We are aiming to elucidate the roles of exosomes from cisplatin-induced dormant lung cancer cells in the formation of pre-metastatic niches in bone marrows.To investigate the differential gene expression profiling between the BMSCs treated with exosomes, we performed RNA-sequencing on BMSCs treated with exo and DORexo.