five

Role of HNF4a in bone

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE190313
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RNAseq of osteocyte and osteoblasts enriched bone fraction from the tibiae of 6 week-old male mice with a conditional deletion of Hnf4a in osteoblasts and and WT littermates. Hnf4αflox/+ (B6.129X1(FVB)-Hnf4αtm1.1Gonz/J) and osteocalcin-Cre (B6.FVB-Tg(BGLAP-cre)1Clem/J) mice were crossed to generate Hnf4αflox/flox (WT) and Hnf4αflox/flox-Cre (Hnf4αcKO). At 6 weeks, mice were sacrificed, and tibiae were excised, epiphyses removed and bone marrow flushed. Total RNA was isolated and submitted for RNAsequencing.
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