Stable states of the FGFR3 mutant network.

The values of nodes representing growth factors and transcription factors are tabled for the relevant stable states in the R-Smad and FGFR3 mutant growth plate. The presence of paracrine signalling is indicated in the table (ext). The situation in the resting zone is virtually unchanged. However, the activity of Sox9 in the proliferation zone is hampered. The stable state representing hypertrophy is also unaffected. For the Smad mutant the proliferative zone is more severely impacted and no expression of Sox9 is predicted. The hypertrophic state can be reached under certain asynchronous updating assumptions, as is apparent from the state transition graph.