hu.MAP 2.0 - Human Protein Complex Map

Proteins interact with each other and organize themselves into macromolecular machines (ie. complexes) to carry out essential functions of the cell. We have a good understanding of a few complexes such as the proteasome and the ribosome but currently we have an incomplete view of all protein complexes as well as their functions. The hu.MAP attempts to address this lack of understanding by integrating several large scale protein interaction datasets to obtain the most comprehensive view of protein complexes. In hu.MAP 2.0 we integrated large scale affinity purification mass spectrometry (AP/MS) datasets, large scale biochemical fractionation data, proximity labeling data and RNA hairpin pulldown data to produce a complex map with over 7k complexes. For details on the datasets and relative publications, please review the hu.MAP 2.0 About page. Node colors represent complex confidence:Extremely High = GreenVery High = BlueHigh = TealMedium High = YellowMedium = Gray Edge colors represent gold standard edges:Positive Test = GreenPositive Train = BlueNegative Test = YellowNegative Train = Red