A Farnesoid X Receptor-Bile Acid Axis Contribute to Immune Evasion in Intestinal Gastric Cancer

Gastric cancer (GC) is the fifth most common type of cancer and the third leading cause of cancer-associated mortality worldwide. The tumor microenvironment (TME) is a complex system composed of extracellular matrix, cytokines, chemokines and non-tumor immune cells which that interact and drive oncogenesis. Recently, immunotherapy is catching attention in several solid tumors including GC but the mechanism of immune-tolerance remains poorly understood. The Farnesoid X receptor (FXR), primary bile acids (BAs) receptor, emerges as modulator of TME and immune cell infiltration in GC. However, the role of BAs in the crosstalk between tumor and immune cells is still unclear. This study aimed to investigate the role of FXR in modulating immune-regulatory networks associated with PD-L1/PD-1 in GC.