Additional file 3: Table S3. of Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus

Hypermethylated CpG sites in PBMC of SLE patients comparing normal controls by genome-wide DNA methylation analysis. Three group comparisons, SLE LN+ vs. NC (S3-1), SLE LN− vs. NC (S3-2), and SLE (LN− and LN+) vs. NC (S3-3), were performed to identify hypermethylated DNA CpG sites by fold change (FC) > 1.2 and q value

本数据集通过全基因组DNA甲基化分析，对比系统性红斑狼疮（systemic lupus erythematosus，SLE）患者外周血单个核细胞（peripheral blood mononuclear cell，PBMC）中的高甲基化CpG位点（CpG site）。共开展三组对照比较：分别为伴狼疮肾炎（lupus nephritis，LN）阳性的SLE患者与正常对照（normal controls，NC）（S3-1）、不伴LN的SLE患者与正常对照（NC）（S3-2），以及涵盖伴与不伴LN的全部SLE患者与正常对照（NC）（S3-3），旨在以折叠变化（fold change，FC）>1.2及q值（q value）为条件，鉴定高甲基化DNA CpG位点。