Validation of NINDS-VCI neuropsychology protocols for vascular cognitive impairment in Taiwan

Objective: To validate the three time-difference neuropsychological protocols developed by the National Institute of Health/National Institute of Neurological Disorders and Stroke (NINDS) and the Canadian Stroke Network for assessment of vascular cognitive impairment (VCI) in Mandarin-speaking subjects and to investigate the clinical application of the shortest form. Methods: Patients aged 50 years or older who had a stroke were invited to participate in the study. Clinical diagnosis of VCI was made. The NINDS-VCI Neuropsychology Protocols, 60-, 30-, and two 5-minute protocols, were administered. The criteria validities of the cognitive protocols against the diagnoses of stroke and VCI were determined via Receiver Operating Characteristic (ROC) analysis. The optimal cut-off point for the 5-minute protocols total score was estimated for clinical use in screening. Results: Eighty-three patients and 53 controls were recruited during the study period. Patients with stroke performed more poo...研究目的：验证由美国国立卫生研究院/美国国立神经疾病与卒中研究所（National Institute of Health/National Institute of Neurological Disorders and Stroke, NINDS）与加拿大卒中网络开发的三款时长各异的神经心理学评估方案，用于汉语使用者的血管性认知损害（vascular cognitive impairment, VCI）评估，并探索其中最简版方案的临床应用价值。 研究方法：招募年龄≥50岁的卒中患者参与本研究，对受试者作出血管性认知损害的临床诊断。施测NINDS-VCI神经心理学评估方案，包含60分钟、30分钟及两种5分钟版方案。采用受试者工作特征（Receiver Operating Characteristic, ROC）分析，评估该系列认知评估方案针对卒中及血管性认知损害诊断的标准效度，并估算5分钟版方案总分的最佳截断值，以供临床筛查使用。 研究结果：本研究期间共纳入83例卒中患者与53例对照受试者，卒中患者的认知表现更为欠佳……