Replication Data for: Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria

<p>We present here the replication dataset used to generate results for the manuscript titled "<a href="">Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria</a>".</p>

<p>The dataset included here comprise of clinical, epidemiological and multiple host genotype (including ABO blood group) data from a cases control study (n = 1403 cases and n = 3929 controls) and longitudinal cohort study (n = 242) of children recruited as part of the Kilifi Health and Demographic Surveillance System (KHDSS) used to look at associations between ABO genotypes and severe malaria or uncomplicated malaria/asymptomatic infection respectively. Also included are data from in vitro experiments on a range of putative P. falciparum virulence phenotypes including P. falciparum rosetting and endothelial cell cytoadhesion generated using human red blood cell samples collected during routine cross-section surveys as part of the Kilifi longitudinal cohort study to used to look at variations in these parasite phenotypes by ABO genotype. </p>

本研究提供了用于生成题为《非O型ABO血型基因型与恶性疟原虫（Plasmodium falciparum）玫瑰花结形成及重症疟疾关联存在差异》的学术手稿结果的重复数据集。

本数据集涵盖临床、流行病学及多宿主基因型（含ABO血型基因型）相关数据，其来源包括两项研究：其一为病例对照研究（纳入1403例病例与3929例对照），其二为依托基利菲健康与人口监测系统（KHDSS）招募的242名儿童的纵向队列研究；前者用于探究ABO基因型与重症疟疾的关联，后者则用于分析ABO基因型与轻症疟疾或无症状感染的关联。此外，数据集还包含一系列体外实验数据：实验利用基利菲纵向队列研究常规横断面调查采集的人类红细胞样本，检测了多种疑似恶性疟原虫毒力表型，包括恶性疟原虫玫瑰花结形成及内皮细胞细胞黏附，以解析ABO基因型对这些寄生虫表型的影响差异。