Additional file 3 of Untargeted metabolomic profiling reveals molecular signatures associated with type 2 diabetes in Nigerians

Additional file 3. Plasma metabolites identified in the replication samples. It depicts comprehensive lists of all named plasma metabolites identified in the 270 participants included in the replication phase of the study sorted by significance level, fold change, and/or by super pathway and includes Table S4A, Heat map of all 1071 metabolites identified in the evaluation cohort (sorted from the lowest FC to the highest FC);Table S4B,Heat map of the 343 differentially expressed metabolites between individuals with T2D and without T2D (p < 0.05 and FDR < 0.1);Table S4C, Heat map of the 343 differentially expressed metabolites between individuals with T2D and without T2D sorted by super pathways; Table S4D, List of shared DEMs between the discovery and the validation cohorts (141 DEMs).

补充文件3：复制样本中鉴定的血浆代谢物。本文件包含本研究复制阶段纳入的270名受试者中鉴定出的所有命名血浆代谢物的完整列表，按显著性水平、倍数变化（fold change）和/或超通路进行排序，并包含以下表格：
表S4A：评估队列中鉴定的全部1071种代谢物的热图（按倍数变化从最低到最高排序）；
表S4B：2型糖尿病（Type 2 Diabetes, T2D）患者与非患者之间343种差异表达代谢物的热图（p<0.05且错误发现率（False Discovery Rate, FDR）<0.1）；
表S4C：按超通路排序的2型糖尿病患者与非患者之间343种差异表达代谢物的热图；
表S4D：发现队列与验证队列共有的差异表达代谢物（Differentially Expressed Metabolites, DEMs）列表（共141种差异表达代谢物）。