IBS BAG

The IBS BAG includes in this proposal IBS teams and external groups from iRTSV/CEA (Grenoble), CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2329 proposal and can be grouped in different topics as follows: host-pathogen interaction, new drug targets, fundamental cellular mechanisms, membrane proteins, intrinsically disordered proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, SAXS, NMR (and cryo-EM), together with other biophysical studies) with the aim to fully understand the complexity of the biological macromolecular systems on study. Some teams are dedicated to serial crystallography and its developments, for which the ESRF-EBS has become the perfect tool.

本提案中的IBS BAG涵盖IBS研究团队，以及来自格勒诺布尔的iRTSV/CEA、圣保罗莱迪朗斯的CEA-Cadarache与布里蒂尼叙尔奥尔日的IRBA的外部合作团队。本团队聚焦蛋白质结构-功能关联研究，研究重点覆盖人类健康、生物技术与方法学领域。绝大多数项目均为MX-2329提案的延续，可归纳为以下研究主题：宿主-病原体互作（host-pathogen interaction）、新型药物靶点、基础细胞机制、膜蛋白、固有无序蛋白质（intrinsically disordered proteins）、生物技术应用及方法学研究。部分项目采用整合研究策略，涵盖X射线晶体学、小角X射线散射（SAXS）、核磁共振（NMR）及冷冻电镜（cryo-EM）等技术，并辅以其他生物物理研究手段，旨在全面解析所研究生物大分子系统的复杂性。另有部分团队致力于连续晶体学技术及其方法开发，ESRF-EBS已成为该领域的理想研究工具。