Retrospective study of patients with cutaneous melanoma treated at the Federal University of São Paulo.

ABSTRACT Objective: to evaluate the characteristics of the patients with cutaneous melanoma treated at the São Paulo Hospital - UNIFESP. Methods: we conducted a retrospective study of 184 cases of cutaneous melanoma. We analyzed information on gender, age, tumor characteristics, histological characteristics and staging. Results: mean age at diagnosis was 58.7 years, with homogeneous age distribution between genders and predominance in white individuals (70.6%). There was a predominance of trunk involvement in men (36.7%) and lower limbs in women (42%). Sun exposure, with sunburns, was more common among males (31.2%) than among females (23.5%). There was an approximately three-fold increase in lymph node involvement when the mitotic index rose from zero (11.9%) to one or more mitosis per field (36.2%). In addition, the greater the Breslow thickness, the greater the lymph node involvement and poor the outcomes: 10.2% when less than 1mm and 59.2% when greater than 4mm. Conclusion: the characteristics of patients with cutaneous melanoma treated at Hospital São Paulo are similar to those found in the literature.

摘要 研究目的：评估圣保罗医院-圣保罗联邦大学（UNIFESP）收治的皮肤黑色素瘤（cutaneous melanoma）患者的临床特征。研究方法：本研究为回顾性研究，共纳入184例皮肤黑色素瘤病例，对患者性别、年龄、肿瘤特征、组织学特征及分期信息进行分析。研究结果：患者确诊时的平均年龄为58.7岁，不同性别患者的年龄分布无显著差异，白人个体占比达70.6%，为主要人群。男性患者肿瘤累及躯干的比例最高（36.7%），女性患者则以下肢受累最为常见（42%）。伴有晒伤史的日晒暴露情况在男性患者中更为多见（31.2%），高于女性患者的23.5%。当有丝分裂指数（mitotic index）从0升至每视野≥1个分裂象时，淋巴结受累率升高约3倍，从11.9%增至36.2%。此外，布雷斯洛厚度（Breslow thickness）越高，淋巴结受累风险越高，患者预后越差：肿瘤厚度小于1mm时淋巴结受累率为10.2%，大于4mm时则升至59.2%。研究结论：圣保罗医院收治的皮肤黑色素瘤患者的临床特征与现有文献报道结果相近。