CHEMICAL CONSTITUENTS DERIVED FROM THE CANARIES MARINE SPONGE Myxilla sp.

Stigmasterols, ceramides, including ceramide-1-phosphates and pyrimidines were identified in an ethanol extract of the marine sponge Myxilla sp. The compounds were identified by MS and 1D- and 2D-NMR techniques. A simple method based on an ultra-high-performance liquid chromatography coupled with tandem mass spectrometry was developed to investigate the production of the aforementioned ceramides. This is the first report on ceramide-1-phosphates from a marine sponge.

从黏海绵属（Myxilla sp.）海洋海绵的乙醇提取物中，鉴定得到豆甾醇类、神经酰胺（包括神经酰胺-1-磷酸酯）以及嘧啶类化合物。上述化合物通过质谱（Mass Spectrometry, MS）、一维（1D-NMR）和二维（2D-NMR）核磁共振波谱技术完成鉴定。本研究开发了一种基于超高效液相色谱-串联质谱联用的简便方法，用于探究前述神经酰胺的生成情况。本研究为首次从海洋海绵中报道神经酰胺-1-磷酸酯类化合物。