Transcriptional profiling of parental and immunotherapy-resistant mouse pancreatic tumor cells

Pancreatic cancer is largely refractory to immunotherapies. This project utilized mouse pancreatic tumor cell line to study tumor cell intrinsic mechanisms undelrying resistance to immunotherapies. RNA-seq analysis revealed that immunotherapy-resistant tumor cells exhibit increased gene expression signature of epithelial-to-mesenchymal transition, compared to the parental tumor cells. Immunotherapy-resistant tumor cells were derived from a parental mouse pancreatic tumor cell line. This project aims to compare gene expression difference between the parental and derived immunotherapy-resistant tumor cells.