PREDICTING THE CONSEQUENCES OF CLINICAL, IMMUNOLOGICAL AND IMMUNOCHEMICAL RESULTS OF RELATED KIDNEY TRANSPLANTATION

The article describes the effectiveness of the acetylation phenotype in clinical use, taking into account the identified relationships between the acetylator status of the donor and recipient, and graft function, the risk of rejection and the choice of immunosuppressive protocol, in terms of predicting the results of related kidney transplantation. The developed method for predicting possible complications after KT taking into account the acetylation phenotype, CYP3A5 genotype and glomerular filtration rate allowed us to classify the risk as low, medium or high.本文阐述了乙酰化表型（acetylation phenotype）在临床应用中的有效性，并结合已明确的供体与受体乙酰化状态、移植物功能、排斥反应风险及免疫抑制方案选择之间的关联，探讨了其在相关肾移植（Kidney Transplantation, KT）预后预测中的应用。本研究开发的综合考量乙酰化表型、CYP3A5基因型（CYP3A5 genotype）与肾小球滤过率（glomerular filtration rate）的肾移植术后并发症预测方法，可将术后风险划分为低、中、高三个等级。