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HIV-1 reverse transcriptase with inhibitor
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创建时间：
2024-02-21
相关数据集
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94)
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94)
NIAID Data Ecosystem30
Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV‑1 Agents
We designed and synthesized a series of chiral indolyarylsulfones (IASs) as new HIV-1 NNRTIs. The new IASs 8–37 showed potent inhibition of the HIV-1 WT NL4-3 strain and of the mutant K103N, Y181C, Y1
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Crystal Structure of HIV-1 Reverse Transcriptase in Complex with GW420867X.
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with GW420867X.
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Design and Development of Highly Potent HIV‑1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants
Design, synthesis, and evaluation of a new class of exceptionally potent HIV-1 protease inhibitors are reported. Inhibitor 5 displayed superior antiviral activity and drug-resistance profiles. In fact
Figshare2017-04-18 更新30
Halogenation-Driven Discovery of Halomethylene-Biphenyl-Diarylpyrimidines as Potent HIV‑1 Non-Nucleoside Reverse Transcriptase Inhibitors with Improved Safety and PK Profiles
To improve the safety and PK profiles of our previously established (S)-4a, a series of halomethylene-linked biphenyl-DAPYs were developed. Enantioselectivity studies of the most promising 5m suggeste
Figshare2025-07-26 更新10
