Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4l

Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4l Descriptor: (2R,3R,4R,5S)-2-[2-(1-adamantyl)ethyl]-2-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Sulzenbacher, G, Roig-Zamboni, V, Moracci, M, Parenti, G, Py, S. Deposit date: 2024-09-18 Release date: 2025-10-01 Last modified: 2025-10-08 Method: X-RAY DIFFRACTION (2.35 Å) Cite: C -Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal alpha-Glucosidase for the Treatment of Pompe Disease. J.Med.Chem., 68, 2025