IBS BAG

The IBS BAG includes in this proposal IBS teams and external groups from CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2398 proposal and can be grouped into different topics as follows: host-pathogen interaction, new drug targets, fundamental cellular mechanisms, membrane proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, SAXS, NMR (and cryo-EM), together with other biophysical studies) with the aim to fully understand the complexity of the biological macromolecular systems on study.

本提案涉及的IBS BAG团队涵盖IBS内部课题组以及来自CEA-Cadarache（圣保罗勒兹迪朗斯）与IRBA（奥尔日河畔布雷蒂尼）的外部合作团体。本团队围绕蛋白质的结构-功能关系展开研究，研究重点涵盖人类健康、生物技术与研究方法学三大方向。本项目绝大多数为MX-2398提案的延续研究，可划分为以下多个研究主题：宿主-病原体互作、新型药物靶点、基础细胞机制、膜蛋白、生物技术应用及研究方法学。部分项目采用整合研究策略，结合X射线晶体学、小角X射线散射（SAXS）、核磁共振波谱（NMR）与冷冻电子显微镜（cryo-EM）等多种生物物理研究手段，旨在全面解析所研究的生物大分子系统的复杂性。